They’ll need to overcome some injury obstacles to get there, though.A pair of starters on the defensive side—defensive tackle Brady Reiff and cornerback Matt Hankins—are expected to be out for the game.Unless something changes, CB Matt Hankins and DT Brady Reiff are out today. Beyond that, I’ve got nothing.— Marc Morehouse (@marcmorehouse) September 14, 2019Reiff has five total tackles and one pass defense on the year. Hankins has four tackles and has knocked down two passes.The Hawkeyes are 2-0 on the year, with wins over Miami (OH) and Rutgers at home.Another player appears to be dealing with an injury, but should be able to go: running back Mekhi Sargent:Iowa RB Mekhi Sargent has a wrap or cast around his right wrist; suffered the injury in practice yesterday. But he’s on the field. Looks like he’s considering giving it a go.CB Matt Hankins & DT Brady Reiff did not get off the team bus, so would consider them out.— Chad Leistikow (@ChadLeistikow) September 14, 2019Sargent would be a big loss for the Hawkeyes is if he’s near 100-percent. He leads the team with 150 rushing yards and has scored once on the ground, and is second on the team with six receptions for 77 yards.Iowa-Iowa State kick off in Ames at 4 p.m. ET. The game will air on FS1. IOWA CITY, IOWA- SEPTEMBER 22: Defensive linemen Chauncey Golston #57 and Brady Reiff #91 of the Iowa Hawkeyes celebrate in the first half after a stop against the Wisconsin Badgers, on September 22, 2018 at Kinnick Stadium, in Iowa City, Iowa. (Photo by Matthew Holst/Getty Images)Iowa at Iowa State is one of the highlights of the Week 3 college football slate. It has been a huge day for the Cy-Hawk rivalry already.College GameDay made its way to Ames for the first time in the show’s history for the game. It was a nice spotlight on what the program called “the best kept secret” in the sport.The main GameDay personalities were split on the result, which is anticipated as a toss-up. With his mascot headgear selection, Lee Corso went with Iowa State, while Kirk Herbstreit thinks the Hawkeyes land a big road win.Iowa is a slight road favorite in this one. The Hawkeyes will enter the game at around -1.5 in the sportsbooks.